This assay is useful in the diagnosis of intravascular coagulation and fibrinolysis / DIC. It also has negative predictive value in excluding the diagnosis of Pulmonary embolism or Deep vein Thrombosis particularly when this assay is combined with clinical information. D-Dimer levels are increased in DIC / Intravascular coagulation, recent bleeding, hematoma, trauma, surgical operation and thromboembolism. High levels may also be seen in pregnancy, liver disease, malignancy, inflammation & chronic hypercoagulable state.